Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes

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Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes

Dexras1 and RHES, monomeric G proteins, are members of small GTPase family that are involved in modulation of pathophysiological processes. Dexras1 and RHES levels are modulated by hormones and Dexras1 expression undergoes circadian fluctuations. Both these GTPases are capable of modulating calcium ion channels which in turn can potentially modulate neurosecretion/hormonal release. These two GT...

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Heterotrimeric G-proteins are signal transducers of heptahelical receptors. They consist of α and βγ subunits, both capable of interacting with several different effectors. Specific domains in their structures enable them to connect different intracellular signaling cascades, such as the adenylyl cyclase, phosphoinositol-bisphosphate or MAP kinase pathways. Their activity is synchronized by sev...

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Structure of small G proteins and their regulators.

In recent years small G proteins have become an intensively studied group of regulatory GTP hydrolases involved in cell signaling. More than 100 small G proteins have been identified in eucaryotes from protozoan to human. The small G protein superfamily includes Ras, Rho Rab, Rac, Sarl/Arf and Ran homologs, which take part in numerous and diverse cellular processes, such as gene expression, cyt...

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ژورنال

عنوان ژورنال: International Journal of Cell Biology

سال: 2014

ISSN: 1687-8876,1687-8884

DOI: 10.1155/2014/308535