Small field with a large impact

Coronary microvasculature: small vessels with large impact.

β-phenylethylamine, a small molecule with a large impact.

During a screen of bacterial nutrients as inhibitors of Escherichia coli O157:H7 biofilm, the Prüß research team made an intriguing observation: among 95 carbon and 95 nitrogen sources tested, β-phenylethylamine (PEA) performed best at reducing bacterial cell counts and biofilm amounts, when supplemented to liquid beef broth medium. This review article summarizes what is known about PEA. After ...

Augmented Chemical Reactions Small molecules with a large impact

Modeling of molecular catalysts in chemistry is still a time consuming process. Where chemists design new catalysts in 2D on a screen or a paper, for making special molecules with a defined chirality, Augmented Chemistry provides an efficient way for designing and interacting with the molecules. This helps to understand the spatial relations between catalyst and reacting molecules and accelerat...

Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability

PURPOSE OF REVIEW Atherosclerotic plaque rupture and subsequent acute events, such as myocardial infarction and stroke, contribute to the majority of cardiovascular-related deaths. Calcification has emerged as a significant predictor of cardiovascular morbidity and mortality, challenging previously held notions that calcifications stabilize atherosclerotic plaques. In this review, we address th...

Energy and field size dependence of a silicon diode designed for small-field dosimetry

Purpose: To investigate the energy dependence/spectral sensitivity of silicon diodes designed for small-field dosimetry and obtain response factors (RFs) for arbitrary photon spectra using Monte Carlo (MC) simulations.   Methods: The EGSnrc user-code DOSRZnrc was used to calculate the dose deposition in water and in the active volume of a stereotactic diode f...