Small-Diameter Blood Vessels Engineered With Bone Marrow–Derived Cells
نویسندگان
چکیده
منابع مشابه
Functional tissue-engineered blood vessels from bone marrow progenitor cells.
OBJECTIVE Stem cells have significant potential for development of cell-based therapeutics for cardiovascular tissue regeneration. METHODS We developed a novel method for isolating smooth muscle cells (SMC) from ovine bone marrow using a tissue-specific promoter and fluorescence-activated cell sorting. RESULTS As compared to vascular SMC, bone marrow-derived smooth muscle progenitor cells (...
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336 ©2013 Society For Biomaterials
متن کاملSonic Hedgehog-activated engineered blood vessels enhance bone tissue formation.
Large bone defects naturally regenerate via a highly vascularized tissue which progressively remodels into cartilage and bone. Current approaches in bone tissue engineering are restricted by delayed vascularization and fail to recapitulate this stepwise differentiation toward bone tissue. Here, we use the morphogen Sonic Hedgehog (Shh) to induce the in vitro organization of an endothelial capil...
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 2005
ISSN: 0003-4932
DOI: 10.1097/01.sla.0000154268.12239.ed