Slow and Fast Inhibition and an H-Current Interact to Create a Theta Rhythm in a Model of CA1 Interneuron Network

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Slow and fast inhibition and an H-current interact to create a theta rhythm in a model of CA1 interneuron network.

The oriens-lacunosum moleculare (O-LM) subtype of interneuron is a key component in the formation of the theta rhythm (8-12 Hz) in the hippocampus. It is known that the CA1 region of the hippocampus can produce theta rhythms in vitro with all ionotropic excitation blocked, but the mechanisms by which this rhythmicity happens were previously unknown. Here we present a model suggesting that indiv...

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Slow and fast inhibition and an h-current interact to create a theta rhythm in a model

The Oriens-lacunosum moleculare (O-LM) subtype of interneuron is a key component in the formation of the theta rhythm (8 12 Hz) in the hippocampus. It is known that the CA1 region of the hippocampus can produce theta rhythms in vitro with all ionotropic excitation blocked, but the mechanisms by which this rhythmicity happens were previously unknown. Here we present a model suggesting that indiv...

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ژورنال

عنوان ژورنال: Journal of Neurophysiology

سال: 2005

ISSN: 0022-3077,1522-1598

DOI: 10.1152/jn.00957.2004