Sleep Deprivation in the Rat: IV. Paradoxical Sleep Deprivation

Caffeine attenuates paradoxical sleep deprivation induced- memory impairment during paradoxical sleep windows in rats

There is considerable evidence to support the hypothesis of relationship between paradoxical sleep (PS) and learning–memory processing. It has been suggested that PS is important in memory retention at the specific time course called PS windows (PSW). The time of PSWs occurrence and duration of these PSWs following the training sessions and, the neurochemical nature of PSWs has not been well kn...

Caffeine attenuates paradoxical sleep deprivation induced- memory impairment during paradoxical sleep windows in rats

There is considerable evidence to support the hypothesis of relationship between paradoxical sleep (PS) and learning–memory processing. It has been suggested that PS is important in memory retention at the specific time course called PS windows (PSW). The time of PSWs occurrence and duration of these PSWs following the training sessions and, the neurochemical nature of PSWs has not been well kn...

Sleep deprivation in the rat: III. Total sleep deprivation.

Ten rats were subjected to total sleep deprivation (TSD) by the disk apparatus. All TSD rats died or were sacrificed when death seemed imminent within 11-32 days. No anatomical cause of death was identified. All TSD rats showed a debilitated appearance, lesions on their tails and paws, and weight loss in spite of increased food intake. Their yoked control (TSC) rats remained healthy. Since dehy...

Paradoxical sleep deprivation increases plasma endothelin levels.

The endothelins (ET-1, 2 and 3) constitute a family of 21 amino acid peptides with potent biological activities. ET-1 is one of the most potent endogenous vasoconstrictors so far identified and its increased concentration in plasma appears to be closely related to the pathogenesis of arterial hypertension as well as to obstructive sleep apnea (OSA). OSA patients exhibit repetitive episodes of a...

Sleep deprivation