SLC54 Mitochondrial pyruvate carriers in GtoPdb v.2023.1

Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes.

At the pyruvate branch point, the fermentative and oxidative metabolic routes diverge. Pyruvate can be transformed either into lactate in mammalian cells or into ethanol in yeast, or transported into mitochondria to fuel ATP production by oxidative phosphorylation. The recently discovered mitochondrial pyruvate carrier (MPC), encoded by MPC1, MPC2, and MPC3 in yeast, is required for uptake of p...

Mitochondrial metabolism of pyruvate in bovine spermatozoa.

Treatment with the polyene antibiotic, filipin, renders the spermatozoan cell membrane permeable to small molecules, but not to the intracellular enzymes aldolase and lactate dehydrogenase. Pyruvate (10 mM) as the sole substrate was metabolized very slowly. L-Carnitine increased pyruvate metabolism 3- to 4-fold and allowed limited rates of oxidative phosphorylation. When spermatozoa treated wit...

Anion Carriers of Mitochondrial Membranes

Role of Mitochondrial Carriers in Metabolic Engineering

Gennaro Agrimi1,2*, Annamaria Russo1,2 and Maria Antonietta Ricci1,2 1Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, 70125 Bari, Italy 2CIRCC Interuniversity Consortium Chemical Reactivity and Catalysis, Via Celso Ulpiani 27, 70126 Bari, Italy *Corresponding author: Gennaro Agrimi, Assistant professor, Department of Biosciences, Biotechnologi...

A re-evaluation of the role of mitochondrial pyruvate transport in the hormonal control of rat liver mitochondrial pyruvate metabolism.

The inhibitor of mitochondrial pyruvate transport alpha-cyano-beta-(1-phenylindol-3-yl)-acrylate was used to inhibit progressively pyruvate carboxylation by liver mitochondria from control and glucagon-treated rats. The data showed that, contrary to our previous conclusions [Halestrap (1978) Biochem. J. 172, 389-398], pyruvate transport could not regulate metabolism under these conditions. This...