SKF-83566, a D1-dopamine receptor antagonist, inhibits the dopamine transporter
نویسندگان
چکیده
منابع مشابه
Dopamine D1 receptor antagonist inhibits swallowing reflex in guinea pigs.
To determine whether dopamine D1receptor antagonist impairs the swallowing reflex and reduces substance P (SP) in the peripheral organs, the swallowing reflex in terms of the number of swallows elicited by injections of three different volumes (0.2, 0.4, and 0.6 ml) of distilled water into the pharynx through a catheter was examined in anesthetized guinea pigs pretreated with Sch-23390. Animals...
متن کاملPolypharmacology of dopamine D1-like receptor antagonists
Drug discovery based on development of selective ligands for a specific target intended to modulate its activity and revert pathophysiological process is now recognized as too simplistic to design effective agent for complex multifactorial diseases, characterized by diverse physiological dysfunctions caused by deregulations of complex networks of proteins. Major challenge in modern drug discove...
متن کاملPhysicochemical properties analysis and dopamine D2 receptor (D2R) docking of zotepine as an atypical antipsychotic antagonist
The main purpose of the present investigation is the study of therapeutically effect of Zotepine in schizophrenia disease treatment. In first step, the molecular structure of the said compound is optimized using density functional theory (DFT) technique by B3LYP functional method at 6-311++G(d,p) level of theory. Then the electronic properties of the title molecule are calculated using frontier...
متن کاملGOLFa Mediates Dopamine D1 Receptor Signaling
It is generally assumed that the coupling of dopamine D1 receptors to adenylyl cyclase is mediated by the stimulatory GTP-binding protein Gs. However, the striatum contains little Gsa subunit, whereas it expresses high levels of Golfa, a close relative of Gsa that is also expressed in olfactory receptor neurons. We used Golfa knockout mice to examine the functional coupling of D1 receptors. We ...
متن کاملA transmembrane domain-derived peptide inhibits D1 dopamine receptor function without affecting receptor oligomerization.
In this study, we show that a peptide based on the sequence of transmembrane domain 6 of the D1 dopamine receptor (D1DR) specifically inhibited D1DR binding and function, without affecting receptor oligomerization. It has been shown that an analogous peptide from the beta2-adrenergic receptor disrupted dimerization and adenylyl cyclase activation in the beta2-adrenergic receptor (Hebert, T. E.,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2011
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.2011.07357.x