Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations
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چکیده
منابع مشابه
Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise.
An active lifestyle is crucial to maintain health into old age; inversely, sedentariness has been linked to an elevated risk for many chronic diseases. The discovery of myokines, hormones produced by skeletal muscle tissue, suggests the possibility that these might be molecular mediators of the whole body effects of exercise originating from contracting muscle fibers. Even though less is known ...
متن کاملSkeletal muscle: an endocrine organ.
Tropism and efficiency of skeletal muscle depend on the complex balance between anabolic and catabolic factors. This balance gradually deteriorates with aging, leading to an age-related decline in muscle quantity and quality, called sarcopenia: this condition plays a central role in physical and functional impairment in late life. The knowledge of the mechanisms that induce sarcopenia and the a...
متن کاملSkeletal muscle is an endocrine organ.
Skeletal muscle plays a key role in postural retention as well as locomotion for maintaining the physical activities of human life. Skeletal muscle has a second role as an elaborate energy production and consumption system that influences the whole body's energy metabolism. Skeletal muscle is a specific organ that engenders a physical force, and exercise training has been known to bring about m...
متن کاملEdward F. Adolph distinguished lecture: muscle as an endocrine organ: IL-6 and other myokines.
Skeletal muscle is an endocrine organ that produces and releases myokines in response to contraction. Some myokines are likely to work in a hormone-like fashion, exerting specific endocrine effects on other organs such as the liver, the brain, and the fat. Other myokines will work locally via paracrine mechanisms, exerting, e.g., angiogenetic effects, whereas yet other myokines work via autocri...
متن کاملProteomics of exercise-induced skeletal muscle adaptations
Introduction The systems biological analysis of dynamic protein constellations and the determination of proteomewide alterations due to physiological adaptations play an increasing role in modern sports medicine. Several large-scale studies on the effect of physical training in humans and relevant animal models have decisively improved our global understanding of the molecular and cellular mech...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine
سال: 2017
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a029793