Six-packed antibodies punch better

Skin biopsy for peripheral neuropathy: is it better to punch or to blister?

Are 25 antibodies better than 1?

In this issue of Blood, Robak et al present data suggesting that rozrolimupab, a firstin-class mixture of 25 recombinant monoclonal IgG1 antibodies against RhD, has efficacy similar to plasma-derived anti-RhD in the treatment of immune thrombocytopenia.1 P lasma-derived anti-RhD, a hyperimmune preparation of IgG that targets the RhD antigen on erythrocytes, is a standard first-line therapy in n...

Science with a punch

There are changes afoot in the way that US granting agencies, most notably the NIH, evaluate proposals. Change can be a good thing, and it is probably high time that the NIH reassessed how grants are evaluated. Frankly, I was becoming blasé about the entire granting process. It seemed that once I became inured to the low probability of funding, competition from the mega-labs, and the shift towa...

Digital Punch Cutting

Digital punch cutting is today’s font technology. There are three different methods available for getting alphabets into digital form : hand-digitizing, auto-tracing and direct design on a workstation screen. The advent of intelligent font scaling requires us to ensure the ‘optical’ quality of a font and also the ‘numerical’ quality of its data; this, in turn, means that new procedures have to ...

Triple punch against trypanosomes

Fat cooperation keeps sleeping sickness at bay, say Molina-Portela et al. (page 1721). The authors find that all three components of a human high density cholesterol complex are needed to kill disease-causing trypanosomes. Trypanosomes cannot synthesize their own fats, so they feed on the host's portion, which in humans and some other primates includes a cholesterol complex known as the trypano...