Sites of reactive oxygen species generation by mitochondria oxidizing different substrates
نویسندگان
چکیده
منابع مشابه
Sites of reactive oxygen species generation by mitochondria oxidizing different substrates☆
Mitochondrial radical production is important in redox signaling, aging and disease, but the relative contributions of different production sites are poorly understood. We analyzed the rates of superoxide/H2O2 production from different defined sites in rat skeletal muscle mitochondria oxidizing a variety of conventional substrates in the absence of added inhibitors: succinate; glycerol 3-phosph...
متن کاملCardiac mitochondria and reactive oxygen species generation.
Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cardiovascular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by the electron transport chain and the proton motive force consisting of a membrane potential (ΔΨ) and a proton gradient (ΔpH). Several factors controllin...
متن کاملProduction of Reactive Oxygen Species by Mitochondria
The mitochondrial respiratory chain is a major source of reactive oxygen species (ROS) under pathological conditions including myocardial ischemia and reperfusion. Limitation of electron transport by the inhibitor rotenone immediately before ischemia decreases the production of ROS in cardiac myocytes and reduces damage to mitochondria. We asked if ROS generation by intact mitochondria during t...
متن کاملMitochondria and reactive oxygen species.
Copyright © 2009 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online 72514 Hypertension is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/HYPERTENSIONAHA.109.130054 2009;53;885-892; originally published online Apr 27, 2009; Hypertension Francesco Addabbo, Monica Montagnani and Michael S. Goligorsky Mitochondria and Reactiv...
متن کاملReactive Oxygen Species Generation by Lunar Simulants
Introduction: The current interest in human exploration of the Moon and past experiences of Apollo astronauts has rekindled research into the harmful effects of Lunar dust on human health. While the mineralogical composition of lunar regolith has been well documented, other factors, such as partial melting due to space weathering, UV irradiation, and dryness may also contribute to the toxicity ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Redox Biology
سال: 2013
ISSN: 2213-2317
DOI: 10.1016/j.redox.2013.04.005