Sister Chromatid Exchanges in Cultured Mammalian Cells Induced by Vinyl Chloride Gas
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Effect of acrolein on phosphoramide mustard-induced sister chromatid exchanges in cultured human lymphocytes.
Although phosphoramide mustard (PM) is generally recognized as being the most genotoxic metabolite of cyclophosphamide (CP), the contribution of acrolein to the cytogenetic toxicity of CP is unclear. Besides covalently binding to DNA, acrolein can inactivate critical proteins necessary for replicative DNA synthesis, RNA transcription, cell membrane integrity, and metabolism of xenobiotic and en...
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The ability of various nitrosoureas to induce sister chromatid exchanges (SCEs) in 9L rat brain tumor cells was investigated. Treatment of cells for 1 hr with the alkylating and cross-linking agents 1,3-bis(2-chloroethyl)-1-nitrosourea or chlorozotocin produced concentration-dependent increases in SCEs; elevations above controls were detected at concentrations of 1 microM or more. Above 0.25 mM...
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ژورنال
عنوان ژورنال: Sangyo Igaku
سال: 1982
ISSN: 0047-1879,1881-1302
DOI: 10.1539/joh1959.24.7_807_2