منابع مشابه
Sirtuin and metabolic kidney disease
Sirtuin is a nicotinamide adenine dinucleotide-dependent deacetylase. One of its isoforms, Sirt1, is a key molecule in glucose, lipid, and energy metabolism. The renal protective effects of Sirt1 are found in various models of renal disorders with metabolic impairment, such as diabetic nephropathy. Protective effects include the maintenance of glomerular barrier function, anti-fibrosis effects,...
متن کاملObesity and Kidney Disease
The rise in the prevalence of chronic kidney disease (CKD) and an increase in the prevalence of obesity in parallel in the recent years is a great concern. CKD increases the rate of cardiovascular disease (CVD) and development of end-stage renal disease, and leads to premature death. Although no direct causality link between obesity and CKD can yet be established, this appears highly probable. ...
متن کاملMetabolic bone disease in chronic kidney disease.
Metabolic bone disease is a common complication of chronic kidney disease (CKD) and is part of a broad spectrum of disorders of mineral metabolism that occur in this clinical setting and result in both skeletal and extraskeletal consequences. Detailed research in that past 4 decades has uncovered many of the mechanisms that are involved in the initiation and maintenance of the disturbances of b...
متن کاملMetabolic syndrome and chronic kidney disease
Metabolic syndrome and chronic kidney disease (CKD) have become global public health problems due to their increasing prevalence and their close associations with cardiovascular events. First recognised by Reaven [1] in 1988, metabolic syndrome (previously known as syndrome X) is a complex pathophysiological issue and essentially considered as an assembly of cardiovascular and metabolic risk fa...
متن کاملMetabolic syndrome and chronic kidney disease
The prevalence of metabolic syndrome (MetS) is increasing worldwide in both developing and developed countries. Experimental and clinical studies have revealed that MetS plays an important role in the development of chronic kidney disease (CKD), which leads to end-stage renal disease. Emerging evidence also suggests that CKD may actually cause MetS since the kidney is an important organ of gluc...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2015
ISSN: 0085-2538
DOI: 10.1038/ki.2015.157