Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease
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چکیده
منابع مشابه
Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease.
Aging and metabolism-related disorders are risk factors for Alzheimer disease (AD). Because sirtuins may increase the life span through regulation of cellular metabolism, we compared the concentration of sirtuin 1 (SIRT1) in the brains of AD patients (n = 19) and controls (n = 22) using Western immunoblots and in situ hybridization. We report a significant reduction of SIRT1 (messenger RNA [mRN...
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OBJECTIVE To test whether plasma tau is altered in Alzheimer disease (AD) and whether it is related to changes in cognition, CSF biomarkers of AD pathology (including β-amyloid [Aβ] and tau), brain atrophy, and brain metabolism. METHODS This was a study of plasma tau in prospectively followed patients with AD (n = 179), patients with mild cognitive impairment (n = 195), and cognitive healthy ...
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To elucidate involvement of tau protein in neurodegenerative processes in Alzheimer disease and related disorders, self-assembly process and degradative process of tau protein were examined. To understand the mechanisms of the aggregation, binding affinity of tau protein to 14-3-3 protein, which converts tau to a filamentous or aggregated form. was investigated employing a surface plasmon reson...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2009
ISSN: 0022-3069,1554-6578
DOI: 10.1097/nen.0b013e3181922348