Sirtuin 1 Is Required for Antagonist-Induced Transcriptional Repression of Androgen-Responsive Genes by the Androgen Receptor
نویسندگان
چکیده
منابع مشابه
A competitive inhibitor that reduces recruitment of androgen receptor to androgen-responsive genes.
The androgen receptor (AR) has a critical role in the growth and progression of androgen-dependent and castration-resistant prostate cancers. To identify novel inhibitors of AR transactivation that block growth of prostate cancer cells, a luciferase-based high-throughput screen of ~160,000 small molecules was performed in cells stably expressing AR and a prostate-specific antigen (PSA)-lucifera...
متن کاملRegulatory regions of androgen-responsive genes.
Androgens are presumed to influence gene transcription by modifying the association of the androgen receptor with specific nuclear sites. However, the details of this process are still obscure. Elucidation of the mechanisms involved is complicated by the diversity of androgen binding within targetcell nuclei and by a lack of understanding of the interaction o f androgen receptors with androgen-...
متن کاملTranscriptional regulation of the TGF-beta1 promoter by androgen receptor.
TGF (transforming growth factor)-beta1 is a multifunctional cytokine that influences homoeostatic processes of various tissues. TGF-beta1 expression is inhibited by androgens in the prostate gland, whereas its expression is enhanced by androgens in highly metastatic prostate cancer cells. Here, we examined regulation of human TGF-beta1 promoter activity by androgen in prostate cancer cells. The...
متن کاملCXCL13 is androgen-responsive and involved in androgen induced prostate cancer cell migration and invasion
Androgen receptor (AR) is a key transcription factor playing a critical role in prostate cancer (PCa) initiation and progression. However, the molecular mechanisms of AR action in prostate cancer are not very clear. CXCL13, known as B cell attracting chemokine1 (BCA-1), is a member of CXC chemokine family and relevant to cancer metastasis. This study shows that CXCL13 is an androgen-responsive ...
متن کاملTranscriptional regulation of prostate kallikrein-like genes by androgen.
Using gene-specific synthetic oligonucleotides the expression and regulation of kallikrein-like genes in the human prostatic cancer cell line LNCaP were studied. Prostate-specific antigen (PSA) and human glandular kallikrein (hGK-1) together constitute a subfamily of serine proteases exclusively produced in the human prostate. RNA analysis revealed that both genes are expressed in LNCaP cells w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2007
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2006-0467