siRNA associated with immunonanoparticles directed against cd99 antigen improves gene expression inhibitionin vivoin Ewing's sarcoma
نویسندگان
چکیده
منابع مشابه
Cell cycle dependency of human sarcoma-associated tumor antigen expression.
An analysis of cell cycle-dependent expression of tumor-associated antigen was performed on a human neurosarcoma cell line (T2 cells). The expression of sarcoma-associated tumor antigen on T2 cells was detected using test sera obtained from sarcoma patients; control sera were from patients with nonsarcoma neoplasias and from normal donors. Results indicate a progressive increase in the antigeni...
متن کاملPrimary Extraskeletal Ewings Sarcoma of Ala of Nose . 1
Extra skeletal Ewing's sarcoma is often described as a tumour involving the soft tissues of the lower extremities and the para vertebral region. Ewing's sarcoma presents a rare tumour of the head and neck, and even rarer in the nasal cavity and/or paranasal sinuses. Primary Ewing’s sarcoma of the ala of the nose has not been commonly described previously in the English literature. We present a ...
متن کاملPrimary Ewings sarcoma of the spine: case report.
Primary malignant sarcomas of the spine are extremely rare. Because of biological heterogeneity, these tumors have variable sensitivity to radiation and chemotherapy. Adequate local control through complete tumor removal is an important therapeutic goal. However, aggressive resection of tumors in the spinal column must be coupled with restoration of spinal column stability and minimization of n...
متن کاملChemically modified siRNA directed against the KDR gene inhibits the proliferation of breast cancer cells.
Vascular endothelial growth factor receptor-2 or kinase insert domain-containing receptor (VEGFR2/KDR) is secreted by most solid tumors, including breast cancer, and is an important mediator of angiogenesis. To observe the effects of KDR gene expression on cell proliferation and the cell cycle in MCF-7 cells in vitro and in vivo, we used chemically modified siRNA directed against KDR. The resul...
متن کاملSiRNA directed against annexin II receptor inhibits angiogenesis via suppressing MMP2 and MMP9 expression.
BACKGROUND/AIMS Annexin II receptor (AXIIR) is able to mediate Annexin II signal and induce apoptosis, but its role in angiogenesis remains unclear. This study tries to investigate the role of AXIIR in angiogenesis and the plausible molecular mechanism. METHODS/RESULTS RNA interference technology was used to silence AXIIR, and the subsequent effects in vitro and in vivo were evaluated thereaf...
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ژورنال
عنوان ژورنال: Journal of Molecular Recognition
سال: 2013
ISSN: 0952-3499
DOI: 10.1002/jmr.2276