Singlet oxygen in copper-catalyzed lipid peroxidation
نویسندگان
چکیده
منابع مشابه
Singlet oxygen production associated with enzyme-catalyzed lipid peroxidation in liver microsomes.
Evidence for the formation of singlet oxygen during the oxidation of NADPH by liver microsomes is presented. The evidence is based primarily on the enzyme-dependent formation of dibenzoylethylene from diphenylfuran, a reaction which is specific for singlet oxygen. The apparent formation of singlet oxygen is coupled to the occurrence of peroxidation of microsomal lipid, a phenomenon known to be ...
متن کاملSuperoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system.
1. Xanthine oxidase acting aerobically upon acetaldehyde was found to cause the peroxidation of linolenate. This was demonstrated by increased absorbance at 233 nm due to diene conjugation and by the detection of a lipid peroxide spot on the thin layer chromatograms. 2. Superoxide dismutase inhibited this lipid peroxidation, as did catalase, thus indicating that both O2- and H2O2 were essential...
متن کاملSuperoxide, Hydrogen Peroxide, and Singlet Oxygen in Lipid Peroxidation by a Xanthine Oxidase System*
1. Xanthine oxidase acting aerobically upon acetaldehyde was found to cause the peroxidation of linolenate. This was demonstrated by increased absorbance at 233 nm due to diene conjugation and by the detection of a lipid peroxide spot on thin layer chromatograms. 2. Superoxide dismutase inhibited this lipid peroxidation, as did catalase, thus indicating that both O,m and H,O, were essential int...
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The effect of alveolar oxygen tension on lung lipid peroxidation during lung ischemia was evaluated by using isolated rat lungs perfused with synthetic medium. After a 5-min equilibration period, global ischemia was produced by discontinuing perfusion while ventilation continued with gas mixtures containing 5% CO2 and a fixed oxygen concentration between 0 and 95%. Lipid peroxidation was assess...
متن کاملProoxidant role of vitamin E in copper induced lipid peroxidation.
When exposed to Cu2+, alpha-tocopherol, in detergent dispersion, is rapidly oxidised. Moreover, if phospholipids and traces of their hydroperoxide derivatives are included in these dispersions, Cu2+ initiates lipid peroxidation, the rate of which is dramatically stimulated by alpha-tocopherol. The observation that the rate of alpha-tocopherol consumption is identical in the absence and in the p...
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ژورنال
عنوان ژورنال: Lipids
سال: 1984
ISSN: 0024-4201,1558-9307
DOI: 10.1007/bf02537409