SINGLE-PHOTON EMISSION COMPUTERIZED TOMOGRAPHY WITH 99mTC-1-THIO-D-GLUCOSE IN THE STAGING OF LYMPHOMAS

Purpose: To study the possibility of using SPECT with a new radiopharmaceutical 99mTc-1-thio-D-glucose (99mTc-TG) for staging lymphomas. Material and methods: The included 53 patients verified diagnosis lymphoma (38 people – main group) adenopathy non-tumor origin (15 - comparison group). All group underwent 99mTc-TG SPECT, CT chest, abdominal organs all interested areas, ultrasound, biopsy followed by histological immunohistochemical studies. Five additional 18F-FDG PET/CT. reference verification methods were IHC examination or, if it was impossible to perform it, clinical observation patient year standard control instrumental studies, PET/CT SPECT. In group, performed once before biopsy. Results: It shown that made possible identify hypermetabolic foci in 75 % affected lymph nodes 81 extranodal formations established diagnostic methods. low sensitivity are due efficiency method detecting lesions cavity associated high background blood activity physiological increase accumulation kidneys bladder. However, allowed visualization nodal 7 9 cases, respectively. A persons showed has specificity (93 %) Conclusion: lymphomas can be used as an investigation lymphoproliferative diseases.