Single-Particle Reconstruction of Biological Molecules-Story in a Sample (Nobel Lecture)
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چکیده
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Nobel Lecture
Ladies and Gentlemen! It gives me great pleasure to be giving the Nobel Lecture before you. In it I shall be reporting on the results of my research for which the Royal Caroline Institute permit me here once again to give public expression of my deepest gratitude has awarded me the Nobel Prize. Naturally I can only present a fraction of these results and I shall have to content myself with tell...
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The sense organs respond to certain changes in their environment by sending messages or signals to the central nervous system. The signals travel rapidly over the long threads of protoplasm which form the sensory nerve fibres, and fresh signals are sent out by the motor fibres to arouse contraction in the appropriate muscles. What kind of signals are these, and how are they elaborated in the sa...
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Up until the year 1921 it was not known how the stimulation of a nerve influenced the effector organ's function, in other words, in what way the stimulation was transmitted to the effector organ from the nerve-ending. In general it was thought that it came about through direct transmission of the stimulation wave from the nerve fibre to the effector organ. But the possibility of transmission by...
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The transmission of the effects of nerve impulses, by the release of chemical agents, first became an experimental reality in 1921. In that year Otto Loewi published the first of the series 1, 2, 3, 4, 5, 6 of papers from his laboratory, which, in the years from 1921-1926, established all the principal characteristics of this newly revealed mechanism, so far as it applied to the peripheral tran...
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Two paths could lead to a cure for progressive paralysis: the rational and the empirical. The rational path appeared to be practical, as since Esmarch and Jessen, in 1858, attention had been drawn to a connection between progressive paralysis and syphilis. If incontestible proof that progressive paralysis was a syphilitic brain disease was first given much later (I mention in this connection th...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2018
ISSN: 1433-7851
DOI: 10.1002/anie.201802770