Single or double? Think zinc!

Do we need zinc to think?

Chelatable Zn(2+), which is found in the synaptic vesicles of certain glutamatergic neurons in several regions of the forebrain, is released during neuronal activity. Zn(2+) exhibits numerous effects on ligand-gated and voltage-dependent ion channels, and released Zn(2+) is therefore likely able to modulate synaptic transmission. The physiologically relevant actions of Zn(2+), however, have rem...

Restricted Single or Double Signed Patterns

Let E n = {[τ ]a = (τ (a1) 1 , . . . , τ (an) n )|τ ∈ Sn, 1 ≤ ai ≤ r} be the set of all signed permutations on the symbols 1, 2, . . . , n with signs 1, 2, . . . , r. We prove, for every 2-letter signed pattern [τ ]a, that the number of [τ ]a-avoiding signed permutations in E n is given by the formula n ∑ j=0 j!(r−1) ( n j 2 . Also we prove that there are only one Wilf class for r = 1, four Wil...

“ To Think , or Not to Think , That Is the Question ”

[To think or not to think, that is the question].

Two studies explored the effects of forget instructions on autobiographical memory at immediate test and following delays of either 12-13 months, or 3-4 months. Using the Autobiographical Think/No-Think procedure (cf., Noreen & MacLeod, 2013), 24 never-depressed participants (Study 1) first generated 12 positive and 12 negative autobiographical memories and associated cues. Participants were th...

Commentary Metal ions and synaptic transmission: Think zinc

Zinc is abundant in the brain, having, after iron, the highest concentration among all transition metals. Most of this brain zinc ('90%) is bound up in metal–protein complexes, such as zinc-finger gene regulatory proteins, in which the zinc is used for enzymatic catalysis or for structural stability, and this tightly complexed portion of the zinc pool is essentially invisible to histochemical s...