Single harmonic-based narrowband magnetic particle imaging

Abstract Magnetic particle imaging (MPI) quantitatively visualizes in vivo superparamagnetic iron oxide nanoparticles (SPIONs), which has shown great promises biomedicine. In this paper, we propose a single harmonic-based narrowband MPI approach via measuring harmonic—3 f 0 harmonic—of the SPIONs induced an excitation magnetic field with frequency = 5 kHz. The scanner is built to scan field-free-point, generated by pair of permanent magnets, through field-of-view, and measure response receive system. dramatically reduces design efforts transmit system noise matching Phantom experiments are performed custom-built evaluate spatial resolution limit detection (LOD). Experimental results indicate that proposed allows 0.5 mm LOD 27 ?g (Fe) ml ?1 (254 ng Fe weight) using Perimag ® SPIONs, can significantly be improved optimized improving circuitry. We believe minimizes hardware but still for good performance terms LOD.