Single dose of oral dexamethasone for outpatient croup

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A Randomized Trial of a Single Dose of Oral Dexamethasone for Mild Croup

From the Department of Pediatrics (C.L.B., J.W., D.W.J.), the Department of Community Health Sciences (R.B.), and the Department of Pharmacology and Therapeutics (D.W.J.), University of Calgary, Calgary, Alta.; the Department of Pediatrics, University of Alberta, Edmonton (T.P.K., L.E.); the Center for Healthcare Innovation and Improvement, University of British Columbia, Vancouver (C.M.); the ...

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A randomized trial of a single dose of oral dexamethasone for mild croup.

BACKGROUND The benefits of dexamethasone treatment for moderate-to-severe croup are well established. However, most children with croup have mild symptoms, and it is unknown whether they would derive the same degree of benefit from dexamethasone treatment as children with more severe disease. METHODS We conducted a double-blind trial at four pediatric emergency departments in which 720 childr...

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Effectiveness of oral or nebulized dexamethasone for children with mild croup.

OBJECTIVE To assess the efficacy of oral dexamethasone or nebulized dexamethasone sodium phosphate in children with mild croup. METHODS Double-blind, placebo-controlled study of 264 children between 6 months and 6 years of age with symptoms of croup for fewer than 48 hours. Patients were excluded if they received racemic epinephrine or corticosteroid treatment. Other exclusion criteria includ...

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Oral dexamethasone led to fewer treatment failures than did nebulized dexamethasone or placebo in children with mild croup.

I n t e r v e n t i o n Children were allocated to oral dexamethasone, 0.6 mg/kg of body weight to a maximum dose of 10 mg, and nebulized placebo (n = 85); nebulized dexamethasone sodium phosphate, 160 μg (n = 91), and oral placebo; or oral and nebulized placebo (n = 88). M a i n o u t c o m e m e a s u r e s The primary outcome was treatment failure (re-evaluation leading to a prescription for...

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Single-Dose Oral Therapy for Uncomplicated Gonorrhea

Background. Progressive resistance to antimicrobial agents has reduced options for gonorrhea therapy worldwide. Solithromycin (CEM-101) is a novel oral fluoroketolide antimicrobial with substantial in vitro activity against Neisseria gonorrhoeae. Methods. We conducted a phase 2 trial of 2 oral doses of solithromycin (1200 and 1000 mg) for treatment of uncomplicated gonorrhea. Results. A total o...

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ژورنال

عنوان ژورنال: BMJ

سال: 1996

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.313.7064.1081