Single-cell metabolic profiling of human cytotoxic T cells
نویسندگان
چکیده
منابع مشابه
Cytotoxic T-Cell Markers and Cytokines in Human Papillomavirus 16
Background and Aim: Cervical cancer is the fourth main cause of mortality among women, and annually about half a million new cases are detected in developed countries. Based on oncological studies, human papillomavirus (HPV) is classified into two categories: high-risk type and low-risk type, and most cases are related to the high-risk type of human papillomavirus. HPV 16 and 18 are among the m...
متن کاملSMARTer T-cell receptor profiling in single cells
T-cell receptor (TCR) profiling of bulk samples has improved our understanding of the TCR repertoire diversity, TCRmediated antigen specificity, and mechanisms of adaptive immune response (Becattini et al. 2015). However, while bulk studies can indicate which clonotypes are expressed and their relative frequencies in the population, it is nearly impossible to determine the proper alpha‐beta (αβ...
متن کاملThe Epigenetic Regulation of Blinatumomab Gene Expression: Tumor Cell-dependent T cell Response against Lymphoma Cells and Cytotoxic Activity
Conventional treatment for cancer such as surgical resection and chemotherapy can cause damage in cases with advanced cancers. Moreover, the identification of tumor-specific targets has great importance in T-cell therapies. For decades, T cell activity has been stimulated to improve anti-tumor activity. Bispecific antibodies have attracted strong interest from pharmaceutical companies, for thei...
متن کاملProfile of interleukin-2 production in human mononuclear cells and T-cell lines
Introduction: Interleukin-2 (IL-2) as a T helper type 1 (Th1) cytokine has an important role Background and Objective: Interleukin-2 (IL-2) as a T helper type 1 (Th1) cytokine has an important role in activation, growth and differentiation of several immune cells. Moreover IL-2 is known as a pro-inflammatory and anti-tumoral cytokine. In addition deysregulation of IL-2 in some diseases such as ...
متن کاملMetabolic insufficiency underlies intratumoral cytotoxic T cell dysfunction
T cells have the remarkable ability to recognize and remove abnormal cells with precision, a feature that is very desirable for the treatment of cancer. However, while T cells specific for tumor antigens are primed and can infiltrate tumors, they are quickly rendered dysfunctional, through both cell intrinsic and cell extrinsic mechanisms. One way that tumors cripple T cell function is through ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2020
ISSN: 1087-0156,1546-1696
DOI: 10.1038/s41587-020-0651-8