SIMULTANEOUS QUANTITATION OF OLMESARTAN MEDOXOMIL AND AMLODIPINE BESYLATE IN COMBINED TABLETS USING HPLC
نویسندگان
چکیده
منابع مشابه
HPLC method development and validation for simultaneous estimation of Olmesartan Medoxomil, Hydrochlorothiazide and Amlodipine Besylate tablets
In the present work for the determination of Olmesartan Medoxomil, Hydrochlorothiazide and Amlodipine a simple, rapid and precise high performance liquid chromatography procedure has been developed and validated. The separation and quantification were achieved on a Cyano C18 column using a mobile phase of filtered and degassed mixture of buffer and acetonitrile in the ratio of 830:170 with of a...
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Background: The present work was undertaken with the aim to develop and validate a rapid and consistent RP-HPLC method in which the peaks will be appear with short period of time as per ICH Guidelines. Materials and Methods: The separation was achieved on a a stainless steel analytical column, Eclipse XDB plus C18 column (4.6 X 150 mm; 5 μm) in an isocratic mode. The mobile phase w...
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The aim of this study was to develop an HPLC method for simultaneous determination of these active compounds and to apply this method to determine the dissolution of AML and OLM from a commercially available tablet. Valsartan (VAL) was used as an internal standard (IS). Separation of AML, OLM and VAL was performed using Phenomenex C18 column (Luna 5 μ, 100A, 250x4.6 mm; California, USA) protect...
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A rapid, simple and sensitive high-performance liquid chromatography (HPLC) method has been developed for quantification of olmesartan medoxomil (OLM) and amlodipine besylate (AM) in plasma. The assay enables the measurement of OLM and AM for therapeutic drug monitoring with a minimum detectable limit of 2 ng mL. The method involves a simple, one-step extraction procedure and analytical recover...
متن کاملSimultaneous Estimation of Amlodipine Besylate and Olmesartan Medoxomil in Combined Tablet Dosage Form Using UV-Spectroscopy and Reverse Phase High-Performance Liquid Chromatography Method
Simple, accurate and precise ultraviolet spectrophotometric and reversed-phase high-performance liquid chromatographic (RP-HPLC) methods for simultaneous estimation of amlodipine besylate (AMLO) and olmesartan medoxomil (OLME) in combined tablet dosage form have been developed and validated. Beer’s law was obeyed in the concentration range of 5-70 and 5-60 μg/mL in methanol at 238 nm and 257 nm...
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ژورنال
عنوان ژورنال: Journal of the Chilean Chemical Society
سال: 2009
ISSN: 0717-9707
DOI: 10.4067/s0717-97072009000300007