Simultaneous Quantitation of Amlodipine Besylate and Olmesartan Medoxomil in Fixed-Dose Combination Tablets: HPLC-DAD Versus UHPLC-DAD
نویسندگان
چکیده
منابع مشابه
HPLC method development and validation for simultaneous estimation of Olmesartan Medoxomil, Hydrochlorothiazide and Amlodipine Besylate tablets
In the present work for the determination of Olmesartan Medoxomil, Hydrochlorothiazide and Amlodipine a simple, rapid and precise high performance liquid chromatography procedure has been developed and validated. The separation and quantification were achieved on a Cyano C18 column using a mobile phase of filtered and degassed mixture of buffer and acetonitrile in the ratio of 830:170 with of a...
متن کاملRP-HPLC-DAD method for determination of olmesartan medoxomil in bulk and tablets exposed to forced conditions.
A simple, sensitive and precise RP-HPLC-DAD method was developed and validated for the determination of olmesartan medoxomil (AT-II receptor blocker) in the presence of its degradation products. Olmesartan medoxomil and all the degradation products were resolved on a C(18) column with the mobile phase composed of methanol, acetonitrile and water (60:15:25, V/V/V, pH 3.5 by orthophosphoric acid)...
متن کاملCritical appraisal of amlodipine and olmesartan medoxomil fixed-dose combination in achieving blood pressure goals
Hypertension remains a significant health burden in the United States, with almost one in three adults affected, and is an independent risk factor for cardiovascular and renal disease. The goal of antihypertensive treatment is to reduce cardiovascular and renal morbidity and mortality by reducing blood pressure (BP). Guidelines recommend a target BP of <140/90 mmHg, with a more stringent goal o...
متن کاملDetermination of in vitro Dissolution Profiles of Amlodipine Besylate and Olmesartan Medoxomil Using a New “HPLC Method”
The aim of this study was to develop an HPLC method for simultaneous determination of these active compounds and to apply this method to determine the dissolution of AML and OLM from a commercially available tablet. Valsartan (VAL) was used as an internal standard (IS). Separation of AML, OLM and VAL was performed using Phenomenex C18 column (Luna 5 μ, 100A, 250x4.6 mm; California, USA) protect...
متن کاملBioequivalence evaluation of two amlodipine salts, besylate and orotate, each in a fixed-dose combination with olmesartan in healthy subjects
A fixed-dose combination of amlodipine and olmesartan is used to treat high blood pressure in patients whose hypertension is not sufficiently controlled with either drug alone. The objective of this study was to evaluate the bioequivalence of two fixed-dose combinations, ie, amlodipine orotate/olmesartan medoxomil 10/40 mg and amlodipine besylate/olmesartan medoxomil 10/40 mg, in healthy subjec...
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ژورنال
عنوان ژورنال: Journal of Chromatographic Science
سال: 2018
ISSN: 0021-9665,1945-239X
DOI: 10.1093/chromsci/bmy004