Simple Analgesics for Arthritis

Simple analgesics for arthritis.

A series of experiments has been carried out with single doses of simple analgesics in patients with rheumatoid arthritis using a consistent polyad design. This method proved to be both valid and useful. Pain relief scores were a better measure of the effectiveness of analgesics than preference.Aspirin, Codis, and Distalgesic were the most effective analgesics tested, with paracetamol, pentazoc...

Use of simple analgesics in rheumatoid arthritis.

The usefulness of anti-inflammatory drugs in rheumatoid arthritis (RA) is beyond dispute. The role of simple analgesics is less clear and has been disputed. A survey of 21 rheumatologists indicated that a majority sometimes supplemented anti-inflammatory treatment of RA with simple analgesics. A random sample of 120 RA patients treated by the same doctors revealed that 47% ranked pain relief as...

Osteoarthritis: simple analgesics versus nonsteroidal antiinflammatory drugs.

Analgesics for osteoarthritis.

Evidence-Based Answer No differences in efficacy for pain and other symptoms of osteoarthritis have been found in direct comparisons of nonselective, selective, and partially selective nonsteroidal anti-inflammatory drugs (NSAIDs). Acetaminophen is modestly inferior to NSAIDs for pain relief. Among topical formulations, diclofenac is comparable to oral NSAIDs for treating localized osteoarthrit...

Opioid Analgesics

Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...