Silybin restored CYP3A expression through the SIRT2/NF-κB pathway in mouse nonalcoholic fatty liver disease
نویسندگان
چکیده
منابع مشابه
Nonalcoholic Fatty Liver Disease Treatment
Nonalcoholic fatty liver disease (NAFLD) is increasing in pediatric age group parallel to the growing prevalence of obesity and overweight all around the world. So changing in life style and interventions on obesogenic environment is cornerstone of NAFLD therapy in obese children. Some experts recommend that children and adolescents be encouraged to follow a low-fat, low-glycemic-index diet t...
متن کاملNonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is known to be associated with an increased risk of colorectal cancer (CRC). However, the relationship between NAFLD and the prognosis of CRC remains unclear. The primary objective of this study was to evaluate the overall survival (OS) and disease-free survival (DFS) rates in patients with CRC and the secondary objective was to compare clinicopathologic...
متن کاملNonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (or NAFLD) is a recently recognized chron ic liver disease, strongly linked to obesity. As the number of obese Americans has doubled in the past three decades, not sur prisingly, NAFLD is becoming increasingly common. The hallmark of persons with NAFLD is having too much fat in the liver. This fat is deposited within the cells of the liver (the medical term is...
متن کاملNonalcoholic fatty liver disease.
N 'onalcoholic fatty liver disease (NAFLD) includes a spectrum of hepatic pathology that resembles alcohol-induced liver disease but develops in individuals who are not heavy drinkers. NAFLD is likely to be the most common cause of chronic liver disease in many countries and may also potentiate liver damage induced by other agents, such as alcohol, industrial toxins, and hepatotrophic viruses. ...
متن کاملNonalcoholic fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) refers to the presence of hepatic steatosis not associated with a significant intake of ethanol. Insulin resistance is central to the pathogenesis of NAFLD; thus obesity, diabetes, and the metabolic syndrome are frequently associated with the disease. Consequently, as these metabolic conditions emerge as major health problems in Western society, it is no...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2021
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.121.000438