Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
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چکیده
منابع مشابه
Sodium overload and water influx activate the NALP3 inflammasome.
The NALP3 inflammasome is activated by low intracellular potassium concentrations [K(+)](i), leading to the secretion of the proinflammatory cytokine IL-1β. However, the mechanism of [K(+)](i) lowering after phagocytosis of monosodium urate crystals is still elusive. Here, we propose that endosomes containing monosodium urate crystals fuse with acidic lysosomes. The low pH in the phagolysosome ...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2008
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.1631