Silencing of glutaminase 1 resensitizes Taxol-resistant breast cancer cells to Taxol
نویسندگان
چکیده
منابع مشابه
Novel multi-kinase inhibitor, T03 inhibits Taxol-resistant breast cancer
Activation of kinase-associated signaling pathways is one of the leading causes of various malignant phenotypes in breast tumors. Strategies of drug discovery and development have investigated approaches to target the inhibition of protein kinase signaling. In the current study, the anti‑tumor activities of a novel multi‑kinase inhibitor, T03 were evaluated in breast cancer. T03 inhibited Taxol...
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Some cancer cells evade chemotherapy by expressing cell membrane pumps to expel toxins. One such pump is the P-glycoprotein, which exports the widely used chemotherapy compound Taxol as it passes through the membrane. To counter P-glycoprotein efflux, Elena Dubikovskaya et al. modified Taxol’s structure, attaching a peptide that alters the mechanism by which the compound enters cells. The new c...
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CBT-1, a natural product, was studied as an MDR modulator with Taxol (135 mg/m2) in an escalating dose Phase I clinical trial. CBT-1 was administered orally at doses from 300 mg/m2 to 500 mg/m2 daily x 7. The MTD was determined to be 500 mg/m2 with moderate nausea and occasional emesis. Side effects were mainly attributable to Taxol rather than the study drug. A total of 18 patients were regist...
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Cancer cells preferentially catalyze glucose through the glycolytic pathway in the presence of adequate oxygen. This phenomenon is known as the Warburg effect. As is the case with numerous cancer therapeutic agents, resistance remains a significant problem when using Taxol® to treat malignancies. The present study reported that expression of pyruvate dehydrogenase kinase 1 (PDK1) was induced by...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2015
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2015.3261