Silencing of genes required for glycosylphosphatidylinositol anchor biosynthesis in Burkitt lymphoma
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چکیده
منابع مشابه
Genome-Wide Screening of Genes Required for Glycosylphosphatidylinositol Biosynthesis
Glycosylphosphatidylinositol (GPI) is synthesized and transferred to proteins in the endoplasmic reticulum (ER). GPI-anchored proteins are then transported from the ER to the plasma membrane through the Golgi apparatus. To date, at least 17 steps have been identified to be required for the GPI biosynthetic pathway. Here, we aimed to establish a comprehensive screening method to identify genes i...
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Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematologic disorder that affects both sexes equally. The biochemical defect in PNH resides in the incomplete enzymatic assembly of glycosylphosphatidylinositol (GPI) anchors used for surface protein attachment. In all PNH patients tested to date, the biosynthetic defect occurs at the addition of N-acetyl-glucosamine to the phospha...
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About 2.5 million people die of Plasmodium falciparum malaria every year. Fatalities are associated with systemic and organ-specific inflammation initiated by a parasite toxin. Recent studies show that glycosylphosphatidylinositol (GPI) functions as the dominant parasite toxin in the context of infection. GPIs also serve as membrane anchors for several of the most important surface antigens of ...
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Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia characterized by the presence of abnormal subpopulations of blood cells that are deficient in surface expression of glycosylphosphatidylinositol (GPI)-anchored proteins. Recent studies showed that the gene termed PIG-A, which participates in the first step of GPI-anchor biosynthesis, is mutated in the abnormal blood cells...
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Ueli Grossniklaus, d,e and David Twell a,1 a Department of Biology, University of Leicester, Leicester LE1 7RH, United Kingdom b Institute of Experimental Botany, Academy of Sciences of the Czech Republic, CZ-16502 Praha 6, Czech Republic c Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom d Institute of Plant Biology and Zür...
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ژورنال
عنوان ژورنال: Experimental Hematology
سال: 2009
ISSN: 0301-472X
DOI: 10.1016/j.exphem.2009.01.003