Silencing Antibiotic Resistance with Antisense Oligonucleotides
نویسندگان
چکیده
Antisense technologies consist of the utilization oligonucleotides or oligonucleotide analogs to interfere with undesirable biological processes, commonly through inhibition expression selected genes. This field holds a lot promise for treatment very diverse group diseases including viral and bacterial infections, genetic disorders, cancer. To date, drugs approved in clinics clinical trials target other than infections. Although several groups companies are working on different strategies, application antisense prokaryotes still lags respect those that human diseases. In cases where focus is pathogens, subset research dedicated produce compounds silence reduce antibiotic resistance Therefore, these will be adjuvants administered which they levels. A varied like phosphorothioate phosphorodiamidate morpholino residues, as well peptide nucleic acids, locked acids bridge latter two gapmer configuration, have been utilized The major mechanisms include eliciting cleavage mRNA by host’s RNase H P, steric hindrance. approaches targeting β-lactams carbapenems, aminoglycosides, chloramphenicol, macrolides, fluoroquinolones. purpose this short review summarize attempts develop inhibit antibiotics.
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2021
ISSN: ['2227-9059']
DOI: https://doi.org/10.3390/biomedicines9040416