منابع مشابه
Pharmacology of sildenafil citrate.
Erectile dysfunction is a common and multi-factorial disease that strongly impairs the quality of life in men. During the past decade, many new therapeutic strategies have become available. But the need for oral treatment was strongly felt. This need appears to have been fulfilled with the introduction of sildenafil. The drug acts by enhancing smooth muscle relaxant effect of nitric oxide. A nu...
متن کاملSildenafil Citrate in Fetal Growth Restriction
BACKGROUND Pregnancies with early onset fetal growth restriction have poor perinatal outcome. Sildenafil citrate (PDE -5 inhibitor) as a vasodilator increases utero-placental blood flow and potentiates fetal growth. CASE PRESENTATION In this study, a case was examined and Sildenafil was administered for her. It was found that Sildenafil improved the uterine blood flow with a favorable fetal o...
متن کاملSildenafil citrate therapy for pulmonary arterial hypertension.
BACKGROUND Sildenafil inhibits phosphodiesterase type 5, an enzyme that metabolizes cyclic guanosine monophosphate, thereby enhancing the cyclic guanosine monophosphate-mediated relaxation and growth inhibition of vascular smooth-muscle cells, including those in the lung. METHODS In this double-blind, placebo-controlled study, we randomly assigned 278 patients with symptomatic pulmonary arter...
متن کاملFixed Drug Eruption Caused by Sildenafil Citrate
Vol. 29, No. 2, 2017 247 Received August 24, 2015, Revised April 7, 2016, Accepted for publication April 10, 2016 Corresponding author: Kui Young Park, Department of Dermatology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 06973, Korea. Tel: 82-2-6299-1525, Fax: 82-2-823-1049, E-mail: [email protected] This is an Open Access arti...
متن کاملEffect of sildenafil citrate on the cardiovascular system.
Sildenafil citrate is a drug commonly used to manage erectile dysfunction. It is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H -pyrazolo[4,3-d]pyrimidin-5-yl)-4 ethoxyphenyl] sulfonyl]-4-methylpiperazine citrate (C22H30N6(O4)S). It is a highly selective inhibitor of cyclic guanine monophosphate-specific phosphodiesterase type 5. In late March through mid-November 1998, ...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2005
ISSN: 1600-5368
DOI: 10.1107/s1600536805002564