Sildenafil Citrate Liposomes for Pulmonary Delivery by Ultrasonic Nebulization
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چکیده
منابع مشابه
Ultrasonic nebulization platforms for pulmonary drug delivery.
IMPORTANCE OF THE FIELD Since the 1950s, ultrasonic nebulizers have played an important role in pulmonary drug delivery. As the process in which aerosol droplets are generated is independent and does not require breath-actuation, ultrasonic nebulizers, in principle, offer the potential for instantaneously fine-tuning the dose administered to the specific requirements of a patient, taking into a...
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BACKGROUND Sildenafil inhibits phosphodiesterase type 5, an enzyme that metabolizes cyclic guanosine monophosphate, thereby enhancing the cyclic guanosine monophosphate-mediated relaxation and growth inhibition of vascular smooth-muscle cells, including those in the lung. METHODS In this double-blind, placebo-controlled study, we randomly assigned 278 patients with symptomatic pulmonary arter...
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Inhalation of iloprost, a stable prostacyclin analogue, is a promising perspective in the treatment of pulmonary hypertension. In initial clinical studies, a conventional jet nebulizer system was successfully used to decrease pulmonary vascular resistance and pressure, requiring however, up to twelve inhalations of 12-15 min per day. The aim of this study was to investigate if the application o...
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ژورنال
عنوان ژورنال: Applied Sciences
سال: 2018
ISSN: 2076-3417
DOI: 10.3390/app8081291