Significant life extension by ten percent dietary restriction
نویسندگان
چکیده
منابع مشابه
Calories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila
Dietary restriction (DR) extends life span in diverse organisms, including mammals, and common mechanisms may be at work. DR is often known as calorie restriction, because it has been suggested that reduction of calories, rather than of particular nutrients in the diet, mediates extension of life span in rodents. We here demonstrate that extension of life span by DR in Drosophila is not attribu...
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Reduced mechanistic target of rapamycin (mTOR) signalling extends lifespan in yeast, nematodes, fruit flies and mice, highlighting a physiological pathway that could modulate aging in evolutionarily divergent organisms. This signalling system is also hypothesized to play a central role in lifespan extension via dietary restriction. By collating data from 48 available published studies examining...
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That tired Ten-Percent claim pops up all the time. Last year, national magazine ads for U.S. Satellite Broadcasting showed a drawing of a brain. Under it was the caption, "You only use 11 percent of its potential." Well, they're a little closer than the ten-percent figure, but still off by about 89 percent. In July 1998, ABC television ran promotional spots for "The Secret Lives of Men," one of...
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Caloric restriction (CR) markedly extends the life of rats, mice and several other species, and it also modulates age-associated physiological deterioration and delays the occurrence and/or slows progression of age-associated diseases. The level of CR that retards the aging processes is a low-intensity stressor, which enhances the ability of rats and mice of all ages to cope with intense stress...
متن کاملSir2-Independent Life Span Extension by Calorie Restriction in Yeast
Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the identification of a Sir2-independent pathway responsible for a majority of the longevity benefit associated with calorie restriction. Deletion of FOB1 and overexpression of SIR2 have been p...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2015
ISSN: 0077-8923,1749-6632
DOI: 10.1111/nyas.12982