Significance of DR-nm23 protein expression in colorectal carcinoma
نویسندگان
چکیده
منابع مشابه
NM23 protein expression in colorectal carcinoma using TMA (tissue microarray): association with metastases and survival.
CONTEXT NM23, a metastasis suppressor gene, may be associated with prognosis in patients with colorectal carcinoma. OBJECTIVE To analyze NM23 expression and its association with the presence of lymph node and liver metastases and survival in patients operated on for colorectal carcinoma. METHODS One hundred thirty patients operated on for colorectal carcinoma were investigated. Tissue micro...
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AIM To explore the relation between heparanase (HPA) and nm23-H1 in hepatocellular carcinoma (HCC), and whether they could be used as valuable markers in predicting post-operative metastasis and recurrence of HCC. METHODS Reverse transcription-polymerase chain reaction and immunohistochemistry (S-P method) were used to measure the expressions of HPA mRNA and nm23-H1 protein in primary tumor t...
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The present study investigated the protein expression level of CXCL12 in colorectal cancer and aimed to elucidate its association with prognosis. CXCL12 positivity in 50% or more of tumor cells was defined as high expression and that in less than 50% of the tumor cells as low expression. CXCL12+ tumor budding at the invasive front was divided into 2 grades: high with 10 or more budding foci per...
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sion of vascular endothelial growth factor (VEGF) and microvessel density in colon cancer tissues [3]. In ovarian cancer, the absence of SPARC upregulated the expressions of VEGF, VEGFR2, MMP-2, and MMP-9, thereby promoting the angiogenic and metastatic potential of these cancers [4]. SPARC is also able to inhibit VEGF-induced integrin activation and down regulation of MMP-2 and MMP-9. There we...
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ژورنال
عنوان ژورنال: World Chinese Journal of Digestology
سال: 2010
ISSN: 2219-2859
DOI: 10.11569/wcjd.v18.i15.1563