Significance and perspectives of telocytes in lung diseases

Telocytes (TCs) are a type of interstitial cells with essential roles in regenerative medicine. TCs spatially exist the stem cell niche and considered ‘stem helper cell’. Mesenchymal stromal therapy has been widely used treating lung diseases, while there is increasing evidence from preclinical studies to show beneficial effects support smooth muscle treat by releasing paracrine factors, exosomes, microvesicles. There still limitations challenges be overcome for TCs-based translational medicine clinical applications, developing new methods improving therapeutic strategies. The present review overviews historical development, morphology spatialization, biomarker specificity values, biological functions, on as well potential mechanisms future perspectives diseases. exert asthma acute injury repairing injured tissues angiogenesis, factors exosomes.