Signalling through the high-affinity IgE receptor FcεRI
نویسندگان
چکیده
منابع مشابه
Human Eosinophils Express the High Affinity IgE Receptor, FcεRI, in Bullous Pemphigoid
Bullous pemphigoid (BP) is an autoimmune blistering disease mediated by autoantibodies targeting BP180 (type XVII collagen). Patient sera and tissues typically have IgG and IgE autoantibodies and elevated eosinophil numbers. Although the pathogenicity of the IgE autoantibodies is established in BP, their contribution to the disease process is not well understood. Our aims were two-fold: 1) To e...
متن کاملThe High Affinity IgE Receptor FcεRI Is Expressed by Human Intestinal Epithelial Cells
BACKGROUND IgE antibodies play a paramount role in the pathogenesis of various intestinal disorders. To gain insights in IgE-mediated pathophysiology of the gut, we investigated the expression of the high affinity IgE receptor Fc epsilonRI in human intestinal epithelium. METHODOLOGY/PRINCIPAL FINDINGS Fc epsilonRI alpha-chain, as detected by immunohistochemistry, was positive in epithelial ce...
متن کاملThe high-affinity IgE receptor (FcεRI) blocks apoptosis in normal human monocytes
Monocytes have a limited life span, and their homeostasis is regulated by programmed cell death in vivo (1, 2). Human monocytes cultured in the absence of appropriate exogenous stimuli undergo apoptosis that is enhanced by serum removal (3). The onset of apoptosis can be prevented by adding activating factors such as LPS, TNF-α, IL-1β, and CD40 ligand; and monocytes receiving such signals diffe...
متن کاملRegulation of the High Affinity IgE Receptor (FcεRI) in Human Neutrophils: Role of Seasonal Allergen Exposure and Th-2 Cytokines
The high affinity IgE receptor, Fc epsilonRI, plays a key role in the immunological pathways involved in allergic asthma. Previously we have demonstrated that human neutrophils isolated from allergic asthmatics express a functional Fc epsilonRI, and therefore it was of importance to examine the factors regulating its expression. In this study, we found that neutrophils from allergic asthmatics ...
متن کاملLysis with Saponin improves detection of the response through CD203c and CD63 in the basophil activation test after crosslinking of the high affinity IgE receptor FcεRI
BACKGROUND The basophil activation test (BAT), in which translocation of markers to the surface of blood basophils is measured in response to allergen by flow cytometry, is a rapid assay that is gaining popularity. Two markers are currently being evaluated for the BAT; CD63 and the lineage-specific CD203c. In a recent report, detection of CD203c after lysis with Saponin was shown to be superior...
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ژورنال
عنوان ژورنال: Nature
سال: 1999
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35037021