Signaling Molecules: Hydrogen Sulfide and Polysulfide
نویسندگان
چکیده
منابع مشابه
Hydrogen sulfide and polysulfides as signaling molecules
Hydrogen sulfide (H2S) is a familiar toxic gas that smells of rotten eggs. After the identification of endogenous H2S in the mammalian brain two decades ago, studies of this molecule uncovered physiological roles in processes such as neuromodulation, vascular tone regulation, cytoprotection against oxidative stress, angiogenesis, anti-inflammation, and oxygen sensing. Enzymes that produce H2S, ...
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SIGNIFICANCE Hydrogen sulfide (H2S) plays roles in many physiological processes, including relaxation of vascular smooth muscles, mediation of neurotransmission, inhibition of insulin signaling, and regulation of inflammation. Also, hydropersulfide (R-S-SH) and polysulfide (-S-Sn-S-) have recently been identified as reactive sulfur species (RSS) that regulate the bioactivities of multiple prote...
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The recognition of hydrogen sulfide (H(2)S) as an endogenously produced gas with signaling potential has stimulated research on a multitude of physiological effects mediated in the cardiovascular, immune, gastrointestinal, genitourinary, endocrine, and central nervous systems. The heightened activity in the area of H(2)S biology led to convening of the first international conference on H(2)S in...
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RATIONALE The recent emergence of hydrogen sulfide (H(2)S) as a potent cardioprotective signaling molecule necessitates the elucidation of its cytoprotective mechanisms. OBJECTIVE The present study evaluated potential mechanisms of H(2)S-mediated cardioprotection using an in vivo model of pharmacological preconditioning. METHODS AND RESULTS H(2)S (100 microg/kg) or vehicle was administered ...
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1School of Kinesiology, Lakehead University, Thunder Bay, Canada P7B 5E1 2Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21218, USA 3Department of Pathophysiology, Nanjing Medical University, Nanjing 210029, China 4Department of Pathophysiology, Harbin Medical University, Harbin 150081, China 5School of Life Science, Shanx...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2015
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2014.5869