Signaling by Steroid Hormones in the 3D Nuclear Space
نویسندگان
چکیده
منابع مشابه
Signaling by Steroid Hormones in the 3D Nuclear Space
Initial studies showed that ligand-activated hormone receptors act by binding to the proximal promoters of individual target genes. Genome-wide studies have now revealed that regulation of transcription by steroid hormones mainly depends on binding of the receptors to distal regulatory elements. Those distal elements, either enhancers or silencers, act on the regulation of target genes by chrom...
متن کاملRapid signaling of steroid hormones in the vertebrate nervous system.
Steroid hormones easily cross the blood-brain barrier because of their physicochemical lipid solubility. The hormones act through nuclear receptor-mediated mechanisms and modulate gene transcription. In contrast to their genomic actions, the non-genomic rapid action of steroid hormones, acting via various types of membrane-associated receptors, reveals pharmacological properties that are distin...
متن کاملSteroid Hormones: Membrane transporters of steroid hormones
The discovery of a plasma membrane ABC protein that exports steroids in yeast highlights the possibility that similar membrane sorting systems in mammalian cells may modulate the access of steroids to their receptors.
متن کاملThe Steroid Hormones in Pregnancy
THE marked changes in hormone production in pregnancy are associated with changes in metabolism and function. Much of the work which has been done and is being continued in the Clinical Research Unit of this department is concerned with the changes in body composition in normal and abnormal pregnancy and the puerperium and in the uterine activity in la;bour. The earlier endocrine work had been ...
متن کاملReceptors and Cell Signaling, Intracellular Receptors —steroid Hormones and No
Soluble extracellular molecules that cross the cell membrane, bind an intracellular receptor, and alter cellular function are essential regulators of mammalian endocrine biology. This article reviews two of the most well-studied and prototypical intracellular receptors: steroid hormone receptors, which are transcriptional regulators, and the nitric oxide receptor, which is soluble guanylate cyc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2018
ISSN: 1422-0067
DOI: 10.3390/ijms19020306