منابع مشابه
Shared signaling pathways among gasotransmitters.
G asotransmitters, including NO, CO, and H2S, are a group of endogenously produced gas molecules that are membranepermeable and share similar molecular targets (1). Gasotransmitters may antagonize or potentiate each other’s cellular effects at three levels: their production, their downstream molecular targets, and the direct chemical interaction among themselves. The study published in PNAS by ...
متن کاملRegulation of colonic ion transport by gasotransmitters.
Gaseous molecules such as nitric oxide (NO), hydrogen sulfide (H₂S), or carbon monoxide (CO) are involved in the regulation of colonic water and salt transport, which can be switched between absorption and secretion. Nitric oxide is produced from the amino acid L-arginine by different isoforms of the enzyme NO synthase, which are expressed both by enteric neurones and by the colonic epithelium....
متن کاملAffinin (Spilanthol), Isolated from Heliopsis longipes, Induces Vasodilation via Activation of Gasotransmitters and Prostacyclin Signaling Pathways
Heliopsis longipes roots have been widely used in Mexican traditional medicine to relieve pain, mainly, toothaches. Previous studies have shown that affinin, the major alkamide of these roots, induces potent antinociceptive and anti-inflammatory activities. However, the effect of H. longipes root extracts and affinin on the cardiovascular system have not been investigated so far. In the present...
متن کاملGasotransmitters: Novel Regulators of Epithelial Na+ Transport?
The vectorial transport of Na(+) across epithelia is crucial for the maintenance of Na(+) and water homeostasis in organs such as the kidneys, lung, or intestine. Dysregulated Na(+) transport processes are associated with various human diseases such as hypertension, the salt-wasting syndrome pseudohypoaldosteronism type 1, pulmonary edema, cystic fibrosis, or intestinal disorders, which indicat...
متن کاملEmerging role of gasotransmitters in renal transplantation.
Once patients with kidney disease progress to end-stage renal failure, transplantation is the preferred option of treatment resulting in improved quality of life and reduced mortality compared to dialysis. Although 1-year survival has improved considerably, graft and patient survival in the long term have not been concurrent, and therefore new tools to improve long-term graft and patient surviv...
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ژورنال
عنوان ژورنال: Science Signaling
سال: 2009
ISSN: 1937-9145
DOI: 10.1126/scisignal.268re2