Signal transduction pathways regulating alternative splicing of tumor-related RAC1b

Regulation of alternative splicing by signal transduction pathways.

Alternative splicing is now recognized as a ubiquitous mechanism for controlling gene expression in a tissue-specific manner. A growing body of work from the past few years as begun to also highlight the existence of networks of signal-responsive alternative splicing in a variety of cell types. While the mechanisms by which signal transduction pathways influence the splicing machinery are relat...

Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways.

The small GTPase Rac1 regulates signaling pathways controlling actin-dependent cell motility as well as gene transcription. An alternative splicing variant Rac1b is overexpressed in a subset of colorectal tumors and is required to sustain tumor cell viability. Thus, it is of therapeutic interest to understand the molecular mechanism behind the overexpression of Rac1b through alternative splicin...

Signal transduction pathways regulating hematopoietic differentiation.

Signals and their transduction pathways regulating alternative splicing: a new dimension of the human genome.

The human genome project demonstrated that alternative splicing of genes is more the rule than the exception. Missplicing events are an important cause and indication of human disease. Changing alternative splicing patterns in response to an external stimulus seems to be a physiological process performed by many cells. Organisms regulate alternative splice site selection by changing the concent...

Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase.

Rac1b was recently identified in malignant colorectal tumors as an alternative splice variant of Rac1 containing a 19-amino acid insertion next to the switch II region. The structures of Rac1b in the GDP- and the GppNHp-bound forms, determined at a resolution of 1.75 A, reveal that the insertion induces an open switch I conformation and a highly mobile switch II. As a consequence, Rac1b has an ...