Siglec-15: an immune system Siglec conserved throughout vertebrate evolution
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چکیده
منابع مشابه
Siglec-15: an immune system Siglec conserved throughout vertebrate evolution.
Siglecs are vertebrate cell-surface receptors that recognize sialylated glycans. Here we have identified and characterized a novel Siglec, named Siglec-15. Siglec-15 is a type-I transmembrane protein consisting of: (i) two immunoglobulin (Ig)-like domains, (ii) a transmembrane domain containing a lysine residue, and (iii) a short cytoplasmic tail. Siglec-15 is expressed on macrophages and/or de...
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Microglia are the resident immune cells of the central nervous system. They can sense intact or lesioned cells and then respond in an appropriate way. Therefore, microglia need recognition receptors that lead to either the activation or the inhibition of the immune response pathways. Most Siglecs contain an immunoreceptor tyrosine based inhibition motif and its signaling leads to the terminatio...
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ژورنال
عنوان ژورنال: Glycobiology
سال: 2007
ISSN: 1460-2423,0959-6658
DOI: 10.1093/glycob/cwm049