SHOX2 gene methylation in Egyptians having lung cancer
نویسندگان
چکیده
منابع مشابه
SHOX2 and WT1 Promoter Methylation Correlates with the Lung Cancer in Iranian Patients
Lung cancer is among the most common cause of cancer death in the world. Since the disease is diagnosed in the middle or late stages of the cancer development a more efficient method for an early diagnosis of the disease is required. The main goal of this study was to investigate the correlation between aberrant promoter methylation of the two genes: SHOX2(Short stature homeobox 2) and WT1(Wilm...
متن کاملAnalysis of SHOX2 methylation as an aid to cytology in lung cancer diagnosis.
BACKGROUND/AIM The Epi proLung® BL Reflex Assay [short stature homeobox gene two methylation assay (SHOX2 assay)] (Epigenomics AG, Berlin, Germany) utilizes quantitative methylation-sensitive real-time polymerase chain reaction (QMSP) for the quantification of methylated short stature homeobox gene two (SHOX2) DNA. In the present study, the diagnostic utility of the SHOX2 assay was tested with ...
متن کاملAssessment of SHOX2 methylation in EBUS-TBNA specimen improves accuracy in lung cancer staging.
BACKGROUND Endobronchial ultrasound with transbronchial needle aspiration (EBUS-TBNA) is a well-established method to assess mediastinal lymph nodes for lung cancer. However, a proportion of patients require further investigation, due to the low negative predictive value (NPV). The objective of this study was to determine whether the assessment of short stature homeobox 2 (SHOX2) DNA methylatio...
متن کاملSHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer in plasma.
INTRODUCTION Recently, analysis of DNA methylation of the SHOX2 locus was shown to reliably identify lung cancer in bronchial aspirates of patients with disease. As a plasma-based assay would expand the possible applications of the SHOX2 biomarker, this study aimed to develop a modified SHOX2 assay for use in a blood-based test and to analyze the performance of this optimized SHOX2 methylation ...
متن کاملDiagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis
The diagnostic value of SHOX2 DNA methylation in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess diagnostic accuracy of SHOX2 DNA methylation in the lymph node, bronchial aspirates, pleural effusion, plasma, and tumor tissue for lung cancer. We conducted a comprehensive literature search in PubMed, Ovid, the Cochrane library, a...
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ژورنال
عنوان ژورنال: Egyptian Journal of Medical Human Genetics
سال: 2020
ISSN: 2090-2441
DOI: 10.1186/s43042-020-00069-1