Should oral contraceptive users be screened for factor V Leiden?

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Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation.

We investigated whether the occurrence of venous thrombosis in young women who use oral contraceptives might be explained by the factor V Leiden mutation, which leads to resistance to activated protein C and enhances susceptibility to thrombosis. We compared 155 consecutive premenopausal women, aged 15 to 49, who had developed deep venous thrombosis in the absence of other underlying diseases, ...

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ژورنال

عنوان ژورنال: BMJ

سال: 1997

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.315.7099.60