Should Lock Therapy Always Be Avoided for Central Venous Catheter–Associated Fungal Bloodstream Infections?

864A Prospective Study of Ethanol Lock Therapy in Children with Central Line-associated Bloodstream Infections

Line-associated Bloodstream Infections Tomohiro Katsuta, MD, PhD; Takumi Moriuchi, MD; Ayano Shinagawa, MD; Ryo Niiya, MD; Yusuke Miyaji, MD, PhD; Yukitsugu Nakamura, MD, PhD; Junichiro Tsuruoka, MD; Satoshi Tateyama, MD; Tadaomi Tokutake, MD, PhD; Natsuki Nakajima, MD, PhD; Toshiro Goshima, MD, PhD; Hitoshi Yamamoto, MD, PhD; Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan

Adjunctive management of central line-associated bloodstream infections with 70% ethanol-lock therapy.

OBJECTIVES Ethanol is bactericidal against most pathogens implicated in central line-associated bloodstream infections (CLABSIs) and biofilms. Current Infectious Diseases Society of America guidelines cite insufficient evidence to support adjunctive ethanol-lock therapy (ELT) for central venous catheter (CVC) salvage in patients with CLABSI in combination with systemic antimicrobial treatment. ...

Impregnated central venous catheters should be readily used to reduce risk of bloodstream infection.

Central venous catheter-related bloodstream infections in cancer patients.

OBJECTIVE To determine the frequency of central venous catheter-related bloodstream infections (CR-BSI) in cancer patients and the antimicrobial susceptibility pattern of the isolates. DESIGN A cross-sectional study. PLACE AND DURATION OF STUDY The study was conducted between April 2002 and March 2003 at the Armed Forces Institute of Pathology, Rawalpindi in collaboration with Oncology Unit...

Debate: Albumin administration should not be avoided

The recent Cochrane report on albumin administration is analysed and criticised on the grounds of clinical methodology, content and interpretation. Although it is naïve and illogical to treat hypoalbuminaemia with albumin infusions, a more balanced view on the use of albumin for resuscitation in acute hypovolaemia is necessary. Once the acute phase of critical illness is past, interstitial volu...