Short term variability of single breath carbon monoxide transfer factor

Short term variability of single breath carbon monoxide transfer factor.

BACKGROUND When monitoring patients with chronic lung disease it is important to distinguish genuine changes in gas transfer over time from natural variability. This study aims to define the coefficient of repeatability for routine measurements of single breath transfer factor (TCO) and transfer coefficient (KCO). METHODS Sixty eight subjects (32 with emphysema, 36 healthy volunteers) had TCO...

Single breath carbon monoxide diffusing capacity (transfer factor)

Variability of the single-breath carbon monoxide transfer factor as a function of inspired oxygen pressure.

We measured single-breath CO transfer factor (TLCO) and alveolar oxygen partial pressure (PAO2) six times at each of three fractions of inspired oxygen (FIO2) (0.17, 0.21, 0.26) in twelve healthy subjects, to determine whether one FIO2 would have the advantage of producing less variable TLCO results than the others. Measured TLCO was adjusted for the increase in carboxyhaemoglobin during the te...

Single breath transfer factor for carbon monoxide in an asymptomatic population of never smokers.

BACKGROUND Data on reference values of transfer factor variables in general populations of asymptomatic never smokers are limited. The aim of this study was to examine the relation between test variables and age, height, haemoglobin concentration and carboxyhaemoglobin concentration. METHODS Measurements of single breath transfer factor for carbon monoxide (TLCO) were obtained for a randomly ...

The single-breath transfer factor for carbon monoxide and respiratory symptoms in a Norwegian community sample.

Reduced single-breath transfer factors of the lung for carbon monoxide are seen in a number of conditions. The hypothesis of the present study was that self-reported respiratory symptoms differ in their prediction of TL,CO level in a general population in Norway. A cross-sectional survey of a general population sample in Norway, made up of 1,275 subjects aged 18-73 yrs, was conducted in 1987-19...