Short Duration Alagebrium Chloride Therapy Prediabetes Does Not Inhibit Progression to Autoimmune Diabetes in an Experimental Model
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چکیده
منابع مشابه
Prediabetes – Preventing progression to diabetes
or impaired glucose tolerance) are at increased risk of developing type 2 diabetes and cardiovascular disease. Evidence supports intensive lifestyle management to help prevent or delay the progression to diabetes. Metformin has also shown benefit but is not approved for this indication in Australia. Prediabetes is a commonly used term to describe patients with elevated blood glucose levels that...
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Background: There is accumulating evidence that Juglans regia L. (GRL) leaf extract has hypoglycemic and antioxidative properties. The present study aimed to investigate the protective effects of GRL leaf extract against diabetic nephropathy (DN). Methods: In total, 28 male adult Sprague-Dawley rats were used. The DN rat model was generated by intraperitoneal injection of a single 55 mg/kg dose...
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BACKGROUND Despite the beneficial effects of alagebrium (ALA), a putative advanced glycation end-product (AGE) breaker, on diabetic nephropathy, its renoprotective mechanisms are incompletely understood. Since oxidative stress exacerbates diabetic renal injury through interaction with AGE, the present study examined the antioxidative property of ALA in db/db mice, mesangial cells cultured under...
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ژورنال
عنوان ژورنال: Metabolites
سال: 2021
ISSN: 2218-1989
DOI: 10.3390/metabo11070426