SHIPping out diabetes—Metformin, an old friend among new SHIP2 inhibitors

A new model for an old friend.

JGP study suggests the anion exchanger AE1 operates via an elevator-like mechanism.

A new career for an old friend

Daylight, rather a fact than a matter of discussion for many millennia, has lost its dominant role in architecture during the years 1950 till 1965. The artificial lighting of interiors had reached its long promised goal and was considered superior to daylighting in quality. In many countries, office buildings and even schools were built without windows because the new techniques of lighting and...

An old friend turns 100.

The Dopamine D2 Receptor: New Surprises from an Old Friend

Drugs acting at dopamine D2 receptors (D2R) are commonly used to alleviate symptoms produced by diseases such as Parkinson's disease, schizophrenia, and depression. A limitation to the use of these drugs is that they sometimes afflict patients with severe side effects. This review discusses recent evidence for several proteins that represent novel mediators of the downstream consequences of D2R...

Dehydroepiandrosterone sulfate and longevity: new clues for an old friend.

D (DHEA) was isolated in urine in 1934, and DHEA 3b-sulfate (DHEAS) was identified 10 years later (1, 2). It took another decade to identify DHEA and DHEAS in peripheral blood (3, 4). More recently, fatty acid esters of DHEA, testosterone, and estradiol (5) were isolated from a variety of tissues, particularly fat (6), and their presence in circulation (5). In 1981, Corpéchot et al. (7) reporte...