منابع مشابه
Shifting Sugars and Shifting Paradigms
No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lactose only when lactose is available and glucose, a better sugar, is not. However...
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Hedgehog (Hh) signaling proteins regulate multiple developmental and adult homeostatic processes. A defining feature of Hh signaling is that relatively small changes in the concentration of Hh ligand elicit dramatically different cellular responses. As a result, the processing, release and trafficking of Hh ligands must be tightly regulated to ensure proper signaling. In addition, sensitive and...
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The ease of travel by jet aircraft has opened up island areas not only for study but also for introduction of weeds, pests, and pathogens. We are at a critical juncture in the study of island organisms, which have become more accessible at the same time that they are vanishing. With the urgency for study of island organisms, we have many new tools, especially molecular ones, which have validate...
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ژورنال
عنوان ژورنال: Nature Clinical Practice Oncology
سال: 2005
ISSN: 1743-4254,1743-4262
DOI: 10.1038/ncponc0345