منابع مشابه
Cost-effectiveness analysis of health technologies when evidence is scarce
.................................................................................................................. I SAMMANFATTNING ............................................................................................. II LIST OF PAPERS ...................................................................................................... III ABBREVIATIONS ...................................
متن کاملIs safe surgery possible when resources are scarce?
The greatest burden of surgical disease exists in low- and middle-income countries, where the quality and safety of surgical treatment cause major challenges. Securing necessary and appropriate medical supplies and infrastructure remains a significant and under-recognised limitation to providing safe and high-quality surgical care in these settings. The majority of surgical instruments are sold...
متن کاملSeasonal differences in cytokine expression in the skin of Shetland ponies suffering from insect bite hypersensitivity.
Insect bite hypersensitivity (IBH) in horses is a seasonal, IgE-mediated, pruritic skin disorder primarily caused by Culicoides spp. We hypothesize that a mixed Th2/Th1-type immune status, off season, alters into Th2-dominated immune reactivity in the skin of IBH-affected ponies in the IBH season. To study these immune response patterns Culicoides-specific IgE levels, skin histopathology and cy...
متن کاملAllergen-Specific Cytokine Polarization Protects Shetland Ponies against Culicoides obsoletus-Induced Insect Bite Hypersensitivity
The immunological mechanisms explaining development of an allergy in some individuals and not in others remain incompletely understood. Insect bite hypersensitivity (IBH) is a common, seasonal, IgE-mediated, pruritic skin disorder that affects considerable proportions of horses of different breeds, which is caused by bites of the insect Culicoides obsoletus (C. obsoletus). We investigated the a...
متن کاملA Non-Synonymous HMGA2 Variant Decreases Height in Shetland Ponies and Other Small Horses
The identification of quantitative trait loci (QTL) such as height and their underlying causative variants is still challenging and often requires large sample sizes. In humans hundreds of loci with small effects control the heritable portion of height variability. In domestic animals, typically only a few loci with comparatively large effects explain a major fraction of the heritability. We in...
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ژورنال
عنوان ژورنال: Journal of Experimental Biology
سال: 2012
ISSN: 1477-9145,0022-0949
DOI: 10.1242/jeb.071571