SHBG-C57BL/ksJ-db/db: A New Mouse Model to Study SHBG Expression and Regulation During Obesity Development
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چکیده
منابع مشابه
Obesity, maternal smoking and SHBG in neonates
BACKGROUND Sex hormone binding globulin (SHBG), a glycoprotein produced by hepatocytes that transports testosterone and other steroids in plasma, is a marker for developing metabolic syndrome and T2DM. SHBG is present in umbilical cord blood where it may be epigenetically regulated. This study was conducted to investigate whether the fetal environment, based on maternal pre-pregnancy weight, pr...
متن کاملSHBG on Testosterone Recovery
lutions give parallel curves for T for both pooled sera. Counts of the tritiated T were identical in both cases (data not shown). Our data, which are in agreement with Masters and Hfihnel (1) and also with Slaats et al. (3), clearly verify that SHBG strongly influences the equilibrium adjustment of the binding reaction between ligand and antibody-the most important step in immunometric measurem...
متن کاملSHBG and polycystic ovarian syndrome (PCOS)
Sex hormone binding globulin (SHBG) is a protein that binds to both testosterone and estradiol. Its amount can vary widely in patients, and if the SHBG is either low or high, the amount of active (bioavailable) testosterone can vary widely. Therefore, it is very important to measure SHBG in all patients being evaluated for polycystic ovarian syndrome, as well as other patients such as patients ...
متن کاملThe (TAAAA)n microsatellite polymorphism in the SHBG gene influences serum SHBG levels in women with polycystic ovary syndrome.
BACKGROUND Hyperandrogenaemia is a common feature of polycystic ovary syndrome (PCOS). The sex hormone-binding globulin (SHBG) gene was proposed as being a PCOS candidate gene. A possible influence of the microsatellite polymorphism (TAAAA)(n) in the SHBG gene on serum SHBG levels in PCOS patients was investigated. METHODS One hundred and twenty-three PCOS patients and 110 age-matched control...
متن کاملSex Hormone-Binding Globulin (SHBG), estradiol and breast cancer.
The human serum Sex Hormone-Binding Globulin (SHBG) plays an important role in breast cancer pathophysiology and risk definition, since it regulates the bioavailable fraction of circulating estradiol. We here summarize data reported over the years concerning the involvement of SHBG and SHBG polymorphisms in the definition of breast cancer risk. We also report what is known about the direct acti...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2015
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2015-1677